Phototransduction in a transgenic mouse model of Nougaret night blindness.

نویسندگان

  • Mustapha Moussaif
  • William W Rubin
  • Vasily Kerov
  • Rebecca Reh
  • Desheng Chen
  • Janis Lem
  • Ching-Kang Chen
  • James B Hurley
  • Marie E Burns
  • Nikolai O Artemyev
چکیده

The Nougaret form of dominant stationary night blindness is linked to a G38D mutation in the rod transducin-alpha subunit (Talpha). In this study, we have examined the mechanism of Nougaret night blindness using transgenic mice expressing TalphaG38D. The biochemical, electrophysiological, and vision-dependent behavioral analyses of the mouse model revealed a unique phenotype of reduced rod sensitivity, impaired activation, and slowed recovery of the phototransduction cascade. Two key deficiencies in TalphaG38D function, its poor ability to activate PDE6 (cGMP phosphodiesterase) and decreased GTPase activity, are found to be the major mechanisms altering visual signaling in transgenic mice. Despite these defects, rod-mediated sensitivity in heterozygous mice is not decreased to the extent seen in heterozygous Nougaret patients.

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Rod and cone function in the Nougaret form of stationary night blindness.

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عنوان ژورنال:
  • The Journal of neuroscience : the official journal of the Society for Neuroscience

دوره 26 25  شماره 

صفحات  -

تاریخ انتشار 2006